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Nervousness and insomnia are the most typical adverse reactions but are generally managed by decreasing dosage and omitting the drug in the afternoon or evening. Other reactions involve hypersensitivity (together with skin rash, urticaria, fever, arthralgia, exfoliative dermatitis, erythema multiforme with histopathological conclusions of necrotizi

Excretion Soon after oral dosing of radiolabeled methylphenidate in people, about ninety% from the radioactivity was recovered in urine. The key urinary metabolite was ritalinic acid, accounting for about 80% from the dose.The 1st compound is an average twoº-amine, and the three beside it are characterized by different levels of nitrogen electron